Vetmec – Studies on Persistant Activity

Persistence of injectable abamectin (Vetmec) compared with other injectable products e.g. Dectomax, Cydectin etc

The following Papers describe studies published in prestigious veterinary journals. They all describe the persistent activity of an injectable abamectin product. The abamectin injectable formulation used in all of the studies was identical to VETMEC.

Entrocasso C, Parra D, Vottero D, Farias M, Uribe LF, Ryan WG. “Comparison of the persistent activity of ivermectin, abamectin, doramectin and moxidectin in cattle.” Vet Rec. 1996 Jan 27; 138(4):91-2. (Link to resource)

6 studies, two per country were conducted. Groups of animals were treated with either the standard injectable formulations of doramectin (Dectomax), moxidectin (Cydectin), Ivermectin (Ivomec) or abamectin (Vetmec).

The results showed that in the control of naturally acquired bovine gastrointestinal parasites, including Cooperia, Ostertagia, Haemaonchus and Oesophagostomum, there was no practical difference in the persistent activity of the above injectable formulations.

Meeus PF, De Bont J, Vercruysse J. “Comparison of the persistent activity of ivermectin, abamectin and doramectin in cattle in Zambia.\” Vet Parasitol. 1997 Jul 1; 70(4):219-24. (Link to resource)

The persistent efficacy of four commercially available macrocyclic lactones (ML) in maintaining reduced faecal egg counts in cattle grazing naturally infested pastures was compared with albendazole, all four ML gave over 95% reduction in cumulative faecal egg counts for 42 days after treatment. The percentage efficacy was still over 84% by day 84 when an average cumulative egg count of 11320 eggs per gram faeces was calculated in group C.

In addition, there was no significant difference in efficacy between the four ML groups at any of the sampling dates. During the trial no significant difference in weight gain between any of the groups was observed.

Rolfe PF, Dawson KL, Soll MD, Nichols GK, Ryan WG. “Persistent efficacy of abamectin and doramectin against gastrointestinal nematodes of cattle.\”Aust Vet J. 1997 Jan; 75(1):33-5. (Link to resource)

The objective was to assess the persistent activity of injectable formulations of abamectin (Vetmec) and doramectin (Dectomax) against gastrointestinal nematodes of cattle.

Results:

Significant reductions in numbers of O ostertagi occurred for both abamectin and doramectin treatments (> 93%) relative to counts in untreated calves, when challenge was administered up to 21 days after treatment. For T axei and Cooperia spp significant reductions occurred when the challenge occurred for 14 days after treatment (99%). Although differences from untreated animals were not significant, the results for H placei suggested high efficacy (> 85%) for up to 21 days for doramectin and up to 28 days for abamectin.

Conclusions:

There was no significant difference between abamectin (Vetmec) anddoramectin (Dectomax) for any parasite at any challenge point, indicating that there is equivalent persistent activity of doramectin and abamectin against important gastrointestinal nematodes of cattle.

Barth D, Ericsson GF, Kunkle BN, Rehbein S, Ryan WG, Wallace DH. “Evaluation of the persistence of the effect of ivermectin and abamectin against gastrointestinal and pulmonary nematodes in cattle.” Vet Rec. 1997 Mar 15; 140(11):278-9. (Link to resource)

The persistence of the effect of ivermectin and abamectin against gastrointestinal nematodes and lungworm in cattle was evaluated in two trials. The cattle were killed 49 to 51 days after treatment and their worm burdens measured.

An efficacy of > 99 per cent was recorded in all the groups demonstrating that the products controlled Haemonchus species, T axei, C oncophora, C punctata and C surnabada for at least two weeks, O ostertagi and O radiatum for at least three weeks and D viviparus for at least four weeks.